Literature summary for 2.3.2.2 extracted from

Grillo, M.P.; Hua, F.; March, K.L.; Benet, L.Z.; Knutson, C.G.; Ware, J.A.
Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat (2008), Chem. Res. Toxicol., 21, 1933-1938.

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Application

Application	Comment	Organism
pharmacology	bile extracts from diclofenac-dosed rats at 200 mg/kg, show the presence of the gamma-GT-mediated diclofenac-S-acyl-glutathione degradation product diclofenac-N-acyl-cysteinylglycine, where a total of 8 microg is excreted 6 h postadministration. When diclofenac-S-acyl-glutathione is incubated with gamma-GT, the GSH adduct is degraded in a linear time-dependent fashion	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
diclofenac-S-acyl-glutathione	competitive, completely reversible	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diclofenac-S-acyl-glutathione + Gly	-	Rattus norvegicus	diclofenac-S-acyl-cysteinylglycine + ?	-	?

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Release 2023.1 (January 2023)