Application | Comment | Organism |
---|---|---|
medicine | given the involvement of GGT in bone and joint diseases characterized by accelerated osteoclast development, GGT may be a novel target for the development of diagnostics and therapeutics | Mus musculus |
Cloned (Comment) | Organism |
---|---|
generation of transgenic mice that overexpress gamma-glutamyltransferase in a tissue-specific manner utilizing the Cre-loxP recombination system. Systemic as well as local production of gamma-glutamyltransferase accelerates osteoclast development and bone resorption in vivo by increasing the sensitivity of bone marrow macrophages to receptor activator of nuclear factor-kappaB ligand, an essential cytokine for osteoclastogenesis. Mutated gamma-glutamyltransferase devoid of enzyme activity is as potent as the wild-type molecule in inducing osteoclast formation, suggesting that gamma-glutamyltransferase acts not as an enzyme but as a cytokine | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
GGT | - |
Mus musculus |