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Literature summary for 2.3.2.2 extracted from

  • Hiramatsu, K.; Asaba, Y.; Takeshita, S.; Nimura, Y.; Tatsumi, S.; Katagiri, N.; Niida, S.; Nakajima, T.; Tanaka, S.; Ito, M.; Karsenty, G.; Ikeda, K.
    Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis (2007), Endocrinology, 148, 2708-2715.
    View publication on PubMed

Application

Application Comment Organism
medicine given the involvement of GGT in bone and joint diseases characterized by accelerated osteoclast development, GGT may be a novel target for the development of diagnostics and therapeutics Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
generation of transgenic mice that overexpress gamma-glutamyltransferase in a tissue-specific manner utilizing the Cre-loxP recombination system. Systemic as well as local production of gamma-glutamyltransferase accelerates osteoclast development and bone resorption in vivo by increasing the sensitivity of bone marrow macrophages to receptor activator of nuclear factor-kappaB ligand, an essential cytokine for osteoclastogenesis. Mutated gamma-glutamyltransferase devoid of enzyme activity is as potent as the wild-type molecule in inducing osteoclast formation, suggesting that gamma-glutamyltransferase acts not as an enzyme but as a cytokine Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
GGT
-
Mus musculus