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Literature summary for 2.3.2.2 extracted from

  • Lherbet, C.; Keillor, J.W.
    Probing the stereochemistry of the active site of gamma-glutamyl transpeptidase using sulfur derivatives of L-glutamic acid (2004), Org. Biomol. Chem., 2, 238-245.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-(methylsulfinyl)butanoic acid competitive Rattus norvegicus
2-amino-4-(methylthio)butanoic acid competitive Rattus norvegicus
2-amino-4-cyanobutanoic acid
-
Rattus norvegicus
2-amino-4-phosphonobutanoic acid competitive Rattus norvegicus
2-amino-4-sulfobutanoic acid uncompetitive Rattus norvegicus
2-amino-4-[(3-((carboxymethyl)amino)-3-oxopropyl)sulfinyl]butanoic acid
-
Rattus norvegicus
2-aminopentanedioic acid competitive Rattus norvegicus
additional information no inhibition: 2-amino-3-(S-methylsulfonimidoyl)propanoic acid, 2-amino-4-(methylsulfonyl)butanoic acid, 5-hydroxy-DL-lysine Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-L-glutamyl-4-nitroanilide + glycylglycine
-
Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine
-
?

Synonyms

Synonyms Comment Organism
gamma-glutamyl transpeptidase
-
Rattus norvegicus
GGT
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.053
-
2-amino-4-[(3-((carboxymethyl)amino)-3-oxopropyl)sulfinyl]butanoic acid
-
Rattus norvegicus
5.9
-
2-amino-4-(methylsulfinyl)butanoic acid pH 8.0, 37°C Rattus norvegicus
11.1
-
2-amino-4-sulfobutanoic acid pH 8.0, 37°C Rattus norvegicus
14.1
-
2-aminopentanedioic acid pH 8.0, 37°C Rattus norvegicus
20.6
-
2-amino-4-cyanobutanoic acid pH 8.0, 37°C Rattus norvegicus
26.9
-
2-amino-4-(methylthio)butanoic acid pH 8.0, 37°C Rattus norvegicus
35.8
-
2-amino-4-phosphonobutanoic acid pH 8.0, 37°C Rattus norvegicus