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Literature summary for 2.3.2.2 extracted from

  • Keillor, J.W.; Menard, A.; Castonguay, R.; Lherbet, C.; Rivard, C.
    Pre-steady-state kinetic studies of rat kidney gamma-glutamyl transpeptidase confirm its ping-pong mechanism (2004), J. Phys. Org. Chem., 17, 529-536.
No PubMed abstract available
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is implicated in cellular detoxification, the biosynthesis of leukotrienes and control of the physiological concentration of glutathione. It also plays important roles in Parkinson‘s disease, diabetes, apoptosis inhibition and cancer drug resistance ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-L-glutamyl-4-nitroanilide + H2O ping-pong mechanism Rattus norvegicus 4-nitroaniline + Glu
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additional information the enzyme is implicated in cellular detoxification, the biosynthesis of leukotrienes and control of the physiological concentration of glutathione. It also plays important roles in Parkinson‘s disease, diabetes, apoptosis inhibition and cancer drug resistance Rattus norvegicus ?
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 ?