Literature summary for 2.3.2.13 extracted from

Wodtke, R.; Hauser, C.; Ruiz-Gomez, G.; Jaeckel, E.; Bauer, D.; Lohse, M.; Wong, A.; Pufe, J.; Ludwig, F.A.; Fischer, S.; Hauser, S.; Greif, D.; Pisabarro, M.T.; Pietzsch, J.; Pietsch, M.; Loeser, R.
Nepsilon-acryloyllysine piperazides as irreversible inhibitors of transglutaminase 2 synthesis, structure-activity relationships, and pharmacokinetic profiling (2018), J. Med. Chem., 61, 4528-4560 .

Inhibitors

Inhibitors	Comment	Organism
1-(6-methylpyridin-2-yl)piperazine	-	Cavia porcellus
1-(6-methylpyridin-2-yl)piperazine	-	Homo sapiens
1-(6-nitropyridin-3-yl)piperazine	-	Cavia porcellus
1-(6-nitropyridin-3-yl)piperazine	-	Homo sapiens
3-iodo-N-[(2S)-1-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Cavia porcellus
3-iodo-N-[(2S)-1-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Homo sapiens
4-fluoro-N-[(2S)-1-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Cavia porcellus
4-fluoro-N-[(2S)-1-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Homo sapiens
4-fluoro-N-[(2S)-1-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Cavia porcellus
4-fluoro-N-[(2S)-1-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-1-oxo-6-[(prop-2-enoyl)amino]hexan-2-yl]benzamide	-	Homo sapiens
5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxamide	-	Cavia porcellus
5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxamide	-	Homo sapiens
5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxylic acid	-	Cavia porcellus
5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxylic acid	-	Homo sapiens
methyl 5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxylate	-	Cavia porcellus
methyl 5-[4-[N2-(phenylacetyl)-N6-(prop-2-enoyl)-L-lysyl]piperazin-1-yl]pyridine-2-carboxylate	-	Homo sapiens
additional information	Nepsilon-acryloyllysine piperazides as irreversible inhibitors of transglutaminase 2, synthesis, structure-activity relationships, and pharmacokinetic profiling, overview. No inhibition by N-[(5R)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	Cavia porcellus
additional information	Nepsilon-acryloyllysine piperazides as irreversible inhibitors of transglutaminase 2, synthesis, structure-activity relationships, and pharmacokinetic profiling, overview. No inhibition by N-[(5R)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	Homo sapiens
N,N-dimethyl-5-(piperazine-1-sulfonyl)naphthalen-1-amine	-	Cavia porcellus
N,N-dimethyl-5-(piperazine-1-sulfonyl)naphthalen-1-amine	-	Homo sapiens
N-[(5S)-5-(2-cyclohexylacetamido)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-(2-cyclohexylacetamido)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(2-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(2-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(2-fluorophenyl)acetamido]-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(2-fluorophenyl)acetamido]-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(3-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(3-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-bromophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-bromophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-chlorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-chlorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-fluorophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-fluorophenyl)acetamido]-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-fluorophenyl)acetamido]-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-iodophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-iodophenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[2-(4-methylphenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[2-(4-methylphenyl)acetamido]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[[(4-fluorophenyl)carbamothioyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[[(4-fluorophenyl)carbamothioyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[[(4-fluorophenyl)carbamoyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[[(4-fluorophenyl)carbamoyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[[(4-fluorophenyl)methyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[[(4-fluorophenyl)methyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-5-[[5-(dimethylamino)naphthalene-1-sulfonyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-5-[[5-(dimethylamino)naphthalene-1-sulfonyl]amino]-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-(4-phenylpiperazin-1-yl)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-(4-phenylpiperazin-1-yl)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-3-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-3-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-4-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-4-yl)piperazin-1-yl]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-[6-(trifluoromethyl)pyridin-3-yl]piperazin-1-yl]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-[6-(trifluoromethyl)pyridin-3-yl]piperazin-1-yl]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-oxo-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]-5-(2,2,2-trifluoroacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-oxo-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]-5-(2,2,2-trifluoroacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(3-methylphenyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(3-methylphenyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(4-fluorobenzoyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(4-fluorobenzoyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(4-nitrobenzoyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(4-nitrobenzoyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(4-nitrophenyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(4-nitrophenyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-bromopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-bromopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-chloropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-chloropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-chloropyridine-2-carbonyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-chloropyridine-2-carbonyl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-fluoropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	determination of the thermodynamic solubility of the compound	Cavia porcellus
N-[(5S)-6-[4-(6-fluoropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	determination of the thermodynamic solubility of the compound	Homo sapiens
N-[(5S)-6-[4-(6-fluoropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-fluoropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-iodopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-iodopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	reversible inhibitor	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	reversible inhibitor	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamothioyl)amino]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamothioyl)amino]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamoyl)amino]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamoyl)amino]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylmethanesulfonyl)amino]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(phenylmethanesulfonyl)amino]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(pyridin-2-yl)acetamido]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(pyridin-2-yl)acetamido]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(thiophen-2-yl)acetamido]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(thiophen-2-yl)acetamido]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(thiophen-3-yl)acetamido]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[2-(thiophen-3-yl)acetamido]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-nitropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	determination of the thermodynamic solubility of the compound	Cavia porcellus
N-[(5S)-6-[4-(6-nitropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	determination of the thermodynamic solubility of the compound	Homo sapiens
N-[(5S)-6-[4-(6-nitropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Mus musculus
N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	reversible inhibitor	Cavia porcellus
N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	reversible inhibitor	Homo sapiens
N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Mus musculus
N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamoyl)amino]hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-[(phenylcarbamoyl)amino]hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-(6-tert-butylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-(6-tert-butylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
N-[(5S)-6-[4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Cavia porcellus
N-[(5S)-6-[4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide	-	Homo sapiens
tert-butyl 4-(4-fluorobenzoyl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(4-fluorobenzoyl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-chloropyridine-2-carbonyl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-chloropyridine-2-carbonyl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-fluoropyridin-2-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-fluoropyridin-2-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-fluoropyridin-3-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-fluoropyridin-3-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-iodopyridin-2-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-iodopyridin-2-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-nitropyridin-2-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-nitropyridin-2-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-phenylpyridin-2-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-phenylpyridin-2-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(6-tert-butylpyridin-2-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(6-tert-butylpyridin-2-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-(pyridin-3-yl)piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-(pyridin-3-yl)piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-[(4-fluorophenyl)methyl]piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-[(4-fluorophenyl)methyl]piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-[6-(methoxycarbonyl)pyridin-3-yl]piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-[6-(methoxycarbonyl)pyridin-3-yl]piperazine-1-carboxylate	-	Homo sapiens
tert-butyl 4-[6-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate	-	Cavia porcellus
tert-butyl 4-[6-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
additional information	-	additional information	kinetics of Z-Glu(HMC)-Gly-OH hydrolysis	Homo sapiens
additional information	-	additional information	kinetics of Z-Glu(HMC)-Gly-OH hydrolysis	Cavia porcellus
additional information	-	additional information	kinetics of Z-Glu(HMC)-Gly-OH hydrolysis	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism
Ca2+	required	Homo sapiens
Ca2+	required	Cavia porcellus
Ca2+	required	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
protein glutamine + alkylamine	Homo sapiens	-	protein N5-alkylglutamine + NH3	-	?
protein glutamine + alkylamine	Cavia porcellus	-	protein N5-alkylglutamine + NH3	-	?
protein glutamine + alkylamine	Mus musculus	-	protein N5-alkylglutamine + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	H0VXN6	-	-
Homo sapiens	O95932	-	-
Homo sapiens	P00488	-	-
Homo sapiens	P21980	-	-
Homo sapiens	P22735	-	-
Homo sapiens	Q08188	-	-
Mus musculus	P21981	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-375 cell	-	Homo sapiens	-
MeWo cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
additional information	measurement of enzyme-catalyzed hydrolysis reactions of water-soluble fluorogenic acyl donor Z-Glu(HMC)-Gly-OH	Homo sapiens	?	-	-
additional information	measurement of enzyme-catalyzed hydrolysis reactions of water-soluble fluorogenic acyl donor Z-Glu(HMC)-Gly-OH	Cavia porcellus	?	-	-
additional information	measurement of enzyme-catalyzed hydrolysis reactions of water-soluble fluorogenic acyl donor Z-Glu(HMC)-Gly-OH	Mus musculus	?	-	-
protein glutamine + alkylamine	-	Homo sapiens	protein N5-alkylglutamine + NH3	-	?
protein glutamine + alkylamine	-	Cavia porcellus	protein N5-alkylglutamine + NH3	-	?
protein glutamine + alkylamine	-	Mus musculus	protein N5-alkylglutamine + NH3	-	?

Synonyms

Synonyms	Comment	Organism
factor XIIIa	-	Homo sapiens
gpTGase 2	-	Cavia porcellus
hfXIIIa	-	Homo sapiens
hTGase 1	-	Homo sapiens
hTGase 2	-	Homo sapiens
hTGase 3	-	Homo sapiens
hTGase 6	-	Homo sapiens
mTGase 2	-	Mus musculus
TGase	-	Homo sapiens
TGase 1	-	Homo sapiens
TGase 2	-	Homo sapiens
TGase 2	-	Cavia porcellus
TGase 2	-	Mus musculus
Tgase 3	-	Homo sapiens
TGase 6	-	Homo sapiens
transglutaminase	-	Homo sapiens
transglutaminase 1	-	Homo sapiens
transglutaminase 2	-	Homo sapiens
transglutaminase 2	-	Cavia porcellus
transglutaminase 2	-	Mus musculus
transglutaminase 3	-	Homo sapiens
transglutaminase 6	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Homo sapiens
30	-	assay at	Cavia porcellus
30	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	assay at	Homo sapiens
6.5	-	assay at	Cavia porcellus
6.5	-	assay at	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
additional information	-	additional information	inhibition kinetics	Homo sapiens
additional information	-	additional information	inhibition kinetics	Cavia porcellus
additional information	-	additional information	inhibition kinetics	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00009	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-3-yl)piperazin-1-yl]hexyl]prop-2-enamide
0.0001	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-nitropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00011	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-fluoropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00014	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-iodopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00017	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-tert-butylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00018	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-chloropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.0002	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide
0.00022	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-bromopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00031	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
0.00034	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide
0.00039	-	pH 6.5, 30°C	Homo sapiens	N-[(5S)-6-[4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide

General Information

General Information	Comment	Organism
additional information	active-site titration using N-[(5S)-6-[4-(6-nitropyridin-3-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide and Z-Glu(HMC)-Gly-OH	Homo sapiens
additional information	docking study and homology structure molecular modeling using the crystal structure of homologous hTGase 2 (PDB ID 2Q3Z) as template	Cavia porcellus
physiological function	transglutaminase 2 (TGase 2)-catalyzed transamidation represents an important post-translational mechanism for protein modification with implications in physiological and pathophysiological conditions, including fibrotic and neoplastic processes	Homo sapiens
physiological function	transglutaminase 2 (TGase 2)-catalyzed transamidation represents an important post-translational mechanism for protein modification with implications in physiological and pathophysiological conditions, including fibrotic and neoplastic processes	Cavia porcellus