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Literature summary for 2.3.2.13 extracted from
- Transglutaminase activity determines nuclear localization of serotonin immunoreactivity in the early embryos of invertebrates and vertebrates (2019), ACS Chem. Neurosci., 10, 3888-3899 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cystamine | - |
Mesocentrotus nudus |  |
| cystamine | - |
Paracentrotus lividus | |
| cystamine | - |
Scaphechinus mirabilis | |
| Monodansylcadaverine | - |
Mesocentrotus nudus | |
| Monodansylcadaverine | - |
Paracentrotus lividus | |
| Monodansylcadaverine | - |
Scaphechinus mirabilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | fluorescence immunohistochemical localization, overview. Brightest 5-HT-ir spots appear at the apical region of all ectodermal cells, and are not associated with nuclei of any cells | Mesocentrotus nudus | - |
- |
| additional information | fluorescence immunohistochemical localization, overview. Brightest 5-HT-ir spots appear at the apical region of all ectodermal cells, and are not associated with nuclei of any cells | Scaphechinus mirabilis | - |
- |
| additional information | fluorescence immunohistochemical localization, overview. Most anti-5-HT staining is associated with nuclear material | Paracentrotus lividus | - |
- |
| nucleus | - |
Paracentrotus lividus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein glutamine + 5-hydroxytryptamine | Mesocentrotus nudus | - |
protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | Paracentrotus lividus | - |
protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | Scaphechinus mirabilis | - |
protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | Mesocentrotus nudus | - |
protein N5-alkylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | Paracentrotus lividus | - |
protein N5-alkylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | Scaphechinus mirabilis | - |
protein N5-alkylglutamine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocentrotus nudus | - |
- |
- |
| Paracentrotus lividus | Q8T316 | - |
- |
| Scaphechinus mirabilis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blastula | - |
Mesocentrotus nudus | - |
| blastula | - |
Paracentrotus lividus | - |
| blastula | - |
Scaphechinus mirabilis | - |
| ectoderm | - |
Mesocentrotus nudus | - |
| ectoderm | - |
Scaphechinus mirabilis | - |
| embryo | - |
Mesocentrotus nudus | - |
| embryo | - |
Paracentrotus lividus | - |
| embryo | - |
Scaphechinus mirabilis | - |
| additional information | enzyme expression analysis and fluorescence histochemical localization, overview | Mesocentrotus nudus | - |
| additional information | enzyme expression analysis and fluorescence histochemical localization, overview | Paracentrotus lividus | - |
| additional information | enzyme expression analysis and fluorescence histochemical localization, overview | Scaphechinus mirabilis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein glutamine + 5-hydroxytryptamine | - |
Mesocentrotus nudus | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | - |
Paracentrotus lividus | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | - |
Scaphechinus mirabilis | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | immunohistochemic detection of 5-HT | Mesocentrotus nudus | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | immunohistochemic detection of 5-HT | Paracentrotus lividus | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + 5-hydroxytryptamine | immunohistochemic detection of 5-HT | Scaphechinus mirabilis | protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | - |
Mesocentrotus nudus | protein N5-alkylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | - |
Paracentrotus lividus | protein N5-alkylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | - |
Scaphechinus mirabilis | protein N5-alkylglutamine + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| transglutaminase | - |
Mesocentrotus nudus |
| transglutaminase | - |
Paracentrotus lividus |
| transglutaminase | - |
Scaphechinus mirabilis |
| transglutaminase-like protein | UniProt | Paracentrotus lividus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation | Mesocentrotus nudus |
| physiological function | serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation | Paracentrotus lividus |
| physiological function | serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation | Scaphechinus mirabilis |
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