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Literature summary for 2.3.2.13 extracted from

  • Jang, G.Y.; Jeon, J.H.; Cho, S.Y.; Shin, D.M.; Kim, C.W.; Jeong, E.M.; Bae, H.C.; Kim, T.W.; Lee, S.H.; Choi, Y.; Lee, D.S.; Park, S.C.; Kim, I.G.
    Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells (2010), Oncogene, 29, 356-367.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in SH-SY5Y, SK-N-SH, A172, U373MG, HeLa, MCF7 and HEK293 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens hypoxia induces TG2 expression through an HIF-1 dependent pathway and concurrently activates intracellular TG2 up

General Information

General Information Comment Organism
physiological function hypoxia induces TG2 expression through an HIF-1 dependent pathway and concurrently activates intracellular TG2. The hypoxiccells overexpressing TG2 show resistance to apoptosis. Hypoxic cells treated with either TG2 inhibitor or small interfering RNA become sensitive to apoptosis. Activation of TG2 in response to hypoxic stress inhibits caspase-3 activity by forming crosslinked multimer, resulting in insoluble aggregates. TG2 also activates nuclear factor kappaB pathway after hypoxic stress, and thereby induces the expression of cellular inhibitor of apoptosis 2 Homo sapiens