Literature summary for 2.3.2.13 extracted from

Yi, S.J.; Groffen, J.; Heisterkamp, N.
Transglutaminase 2 regulates the GTPase-activating activity of Bcr (2009), J. Biol. Chem., 284, 35645-35651.

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Protein Variants

Protein Variants	Comment	Organism
C277S	mutation in active site	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	TG2 binds to the Rac-binding pocket in the GTPase-activating domains of regulator proteins Bcr and Abr, blocks Bcr activity and, through this mechanism, increases levels of active GTP-bound Rac and EGF-stimulated membraneruffling. Bcr exhibits preferential binding to the non-compacted conformation of TG2, in which its catalytic domain is exposed, but transamidation is not needed for the interaction	Homo sapiens

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Release 2023.1 (January 2023)