Literature summary for 2.3.2.13 extracted from

Siegel, M.; Strnad, P.; Watts, R.E.; Choi, K.; Jabri, B.; Omary, M.B.; Khosla, C.
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury (2008), PLoS ONE, 3, e1861.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-N-(((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methyl)-2-(1-(dimethylamino)naphthalene-5-sulfonamido)-3-(1H-indol-3-yl)propanamide	the majority of cellular TG2 cannot be inhibited in intact cells. The inhibitor potently inhibits cell lysate TG2 activity in the presence of calcium	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in vivo. Physical or certain types of chemical injury can lead to rapid enzymatic activation	Mus musculus	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	calcium in the putrescine incorporation assay buffer results in activation of previously latent TG2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
small intestine mucosa	acute poly(I:C) injury results in rapid TG2 activation	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
TG2	-	Mus musculus
transglutaminase 2	-	Mus musculus

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Release 2023.1 (January 2023)