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Literature summary for 2.3.2.13 extracted from

  • Brobey, R.K.; Soong, L.
    Leishmania species: evidence for transglutaminase activity and its role in parasite proliferation (2006), Exp. Parasitol., 114, 94-102.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cystamine
-
Leishmania amazonensis
iodoacetamide
-
Leishmania amazonensis
Monodansylcadaverine
-
Leishmania amazonensis
additional information not inhibitory: didansylcadaverine Leishmania amazonensis

Metals/Ions

Metals/Ions Comment Organism Structure
additional information enzyme is dependent on Ca2+ Leishmania amazonensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leishmanolysin + alkylamine Leishmania amazonensis
-
?
-
?
additional information Leishmania amazonensis major substrates of enzyme are in the range of 50-75 kDA ?
-
?
myo-inositol-1-phosphate synthase + alkylamine Leishmania amazonensis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Leishmania amazonensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote comparable activity in both promastigote and amastigote Leishmania amazonensis
-
promastigote comparable activity in both promastigote and amastigote Leishmania amazonensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leishmanolysin + alkylamine
-
Leishmania amazonensis ?
-
?
additional information major substrates of enzyme are in the range of 50-75 kDA Leishmania amazonensis ?
-
?
myo-inositol-1-phosphate synthase + alkylamine
-
Leishmania amazonensis ?
-
?