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Literature summary for 2.3.2.13 extracted from

  • Stephens, P.; Grenard, P.; Aeschlimann, P.; Langley, M.; Blain, E.; Errington, R.; Kipling, D.; Thomas, D.; Aeschlimann, D.
    Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses (2004), J. Cell Sci., 117, 3389-3403.
    View publication on PubMed
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Application

Application Comment Organism
medicine enzyme activity is implicated in the pathogenesis of diseases related to wound healing and neovascularization. Enzyme deficient cells display normal attachment but delayed spreading on extracellular matrix substrates and defects in motility unrelated to crosslinking. Enzyme deficient fibroblasts have defects in focal adhesion turnover and stress fibre formation, show changes in focal adhesion kinase phosphorylation and fail to activate protein kinase C alpha Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is involved in the control of dynamic adhesion formation in cell spreading and migration via regulation of phospholipase C activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 patients with deficiencies in enzyme activity
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary foreskin fibroblast Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in the control of dynamic adhesion formation in cell spreading and migration via regulation of phospholipase C activity Homo sapiens ?
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 ?