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Literature summary for 2.3.2.13 extracted from

  • Puzkin, E.G.; Raghuraman, V.
    Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard (1985), J. Biol. Chem., 260, 16012-16020.
    View publication on PubMed
Search for more literature for 2.3.2.13

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin/Ca2+ 0.01-0.2 mM, 3fold activation, inhibition above 0.3 mM, kinetics Gallus gallus
Calmodulin/Ca2+ 0.01-0.2 mM, 3fold activation, inhibition above 0.3 mM, kinetics Homo sapiens
thrombin slight activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine reverses calmodulin enzyme stimulation Gallus gallus
chlorpromazine reverses calmodulin enzyme stimulation Homo sapiens
iodoacetamide factor XIIIa; not inhibited in the absence of Ca2+, calmodulin regulated transglutaminases is not inhibited Gallus gallus
iodoacetamide factor XIIIa; not inhibited in the absence of Ca2+, calmodulin regulated transglutaminases is not inhibited Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
 casein plasma factor XII, actin Gallus gallus
0.007
-
 actin platelet transglutaminase Homo sapiens
0.011
-
 casein platelet transglutaminase Homo sapiens
0.012
-
 casein gizzard transglutaminase Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Gallus gallus
Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein-bound gamma-glutamine + alkylamine Gallus gallus last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine Homo sapiens last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
co-purified with alpha-actinin Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-
gizzard smooth muscle Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
monodansyl- cadaverine + actin
-
 Homo sapiens ?
-
 ?
N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + casein
-
 Gallus gallus ?
-
 ?
N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + casein
-
 Homo sapiens ?
-
 ?
N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + F-actin trivial name dansylcadaverine Gallus gallus ?
-
 ?
N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + F-actin trivial name dansylcadaverine Homo sapiens ?
-
 ?
protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Gallus gallus protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Homo sapiens protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Gallus gallus protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Gallus gallus protein N5-alkylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
 ?