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Literature summary for 2.3.2.13 extracted from

  • Delcros, J.G.; Roch, A.M.; Quash, G.
    The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine (1984), FEBS Lett., 171, 221-226.
    View publication on PubMed
Search for more literature for 2.3.2.13

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine 2.6 mM, 50% inhibition of putrescine transfer to casein, suicide substrate, irreversible, competitive to putrescine or fibrinonectin Cavia porcellus
ornithine weak, suicide substrate in the presence of casein Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.17
-
 putrescine
-
 Cavia porcellus
1.35
-
 ornithine
-
 Cavia porcellus
2.1
-
 alpha-difluoromethylornithine
-
 Cavia porcellus
2.1
-
 alpha-difluoroornithine suicide substrate Cavia porcellus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-difluoromethylornithine + casein
-
 Cavia porcellus ?
-
 ?
alpha-difluoroornithine + casein suicide substrate Cavia porcellus ?
-
 ?
ornithine + casein
-
 Cavia porcellus ?
-
 ?
putrescine + casein in vitro acceptor Cavia porcellus ?
-
 ?
putrescine + fibronectin in vivo acceptor Cavia porcellus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cavia porcellus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.28
-
 alpha-difluoromethylornithine
-
 Cavia porcellus