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Literature summary for 2.3.2.12 extracted from

  • Marks, J.; Kannan, K.; Roncase, E.J.; Klepacki, D.; Kefi, A.; Orelle, C.; Vazquez-Laslop, N.; Mankin, A.S.
    Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center (2016), Proc. Natl. Acad. Sci. USA, 113, 12150-12155 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.12

Inhibitors

Inhibitors Comment Organism Structure
chloramphenicol CHL, inhibits protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Analysis of the binding site of CHL in the peptidyl transferase center of the 50S ribosomal subunit, overview. The identity of the penultimate residue of the nascent peptide is critical for the inhibitory activity, specificity and mechanism Escherichia coli
linezolid LZD, inhibits protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Analysis of the binding site of LZD in the peptidyl transferase center of the 50S ribosomal subunit, overview. The identity of the penultimate residue of the nascent peptide is critical for the inhibitory activity, specificity and mechanism Escherichia coli
additional information reevaluation of the mechanism of inducible CHL resistance. CHL and LZD poorly inhibit peptide bond formation when glycine residues are involved. Induction of CHL resistance genes relies on the stimulatory effect of the penultimate residue of the nascent chain on drug action Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
 Escherichia coli 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2 Escherichia coli
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Escherichia coli tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Synonyms

Synonyms Comment Organism
peptidyl transferase center
-
 Escherichia coli
PTC
-
 Escherichia coli