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Literature summary for 2.3.2.12 extracted from
- Structure/function correlation of spermine-analog-induced modulation of peptidyltransferase activity (1998), Eur. J. Biochem., 258, 437-444.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N1,N12-Diacetylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli |  |
| N1,N12-dipivaloylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli | |
| N1-acetylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N1,N12-Diacetylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli | |
| N1,N12-dipivaloylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli | |
| N1-acetylspermine | both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration | Escherichia coli | |
| spermine | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| ribosome | - |
Escherichia coli | 5840 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AcPhe-tRNA + puromycin | - |
Escherichia coli | tRNA + AcPhe-puromycin | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.2 | - |
spermine | - |
Escherichia coli | |
| 5 | - |
N1-acetylspermine | - |
Escherichia coli | |
| 12.9 | - |
N1,N12-dipivaloylspermine | - |
Escherichia coli | |
| 33 | - |
N1,N12-Diacetylspermine | - |
Escherichia coli | |
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