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Literature summary for 2.3.2.12 extracted from
- The effect of ribosomal peptidyl-transferase inhibitors is antagonized by elongation factor G with GTP (1976), FEBS Lett., 70, 101-104.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Amicetin | - |
Escherichia coli |  |
| chloramphenicol | - |
Escherichia coli | |
| Gougerotin | - |
Escherichia coli | |
| Griseoviridin | - |
Escherichia coli | |
| Lincomycin | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| ribosome | - |
Escherichia coli | 5840 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | Escherichia coli | - |
tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
| peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | Escherichia coli MRE 600 | - |
tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
MRE-600 | - |
| Escherichia coli MRE 600 | - |
MRE-600 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | in the presence of elongation factor EF-G with GTP the poly-U-directed translation is much more resistant to inhibitors of the peptidyl-transferase | Escherichia coli | ? | - |
? | |
| additional information | in the presence of elongation factor EF-G with GTP the poly-U-directed translation is much more resistant to inhibitors of the peptidyl-transferase | Escherichia coli MRE 600 | ? | - |
? | |
| peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | - |
Escherichia coli | tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
| peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | - |
Escherichia coli MRE 600 | tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
| phenylalanyl-tRNA + puromycin | poly-U-directed translation system | Escherichia coli | tRNA + phenylalanyl-puromycin | - |
? | |
| phenylalanyl-tRNA + puromycin | poly-U-directed translation system | Escherichia coli MRE 600 | tRNA + phenylalanyl-puromycin | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
enzyme assay | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | 7.4 | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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