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Literature summary for 2.3.2.10 extracted from

  • Chemama, M.; Fonvielle, M.; Arthur, M.; Valery, J.M.; Etheve-Quelquejeu, M.
    Synthesis of stable aminoacyl-tRNA analogues containing triazole as a bioisoster of esters (2009), Chemistry, 15, 1929-1938.
    View publication on PubMed

Application

Application Comment Organism
medicine Fem transferases are considered attractive targets for the development of novel antibiotics active against multiply resistant bacteria Weissella viridescens

Inhibitors

Inhibitors Comment Organism Structure
aminoacyl-tRNA analogue C
-
Weissella viridescens
aminoacyl-tRNA analogue C'
-
Weissella viridescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Weissella viridescens catalyses the transfer of L-Ala from Ala-tRNAAla to the peptidoglycan precursor UDP-MurNAc-pentapeptide in order to introduce the first residue of an L-Ala-L-Ser-L-Ala side chain ?
-
?

Organism

Organism UniProt Comment Textmining
Weissella viridescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyses the transfer of L-Ala from Ala-tRNAAla to the peptidoglycan precursor UDP-MurNAc-pentapeptide in order to introduce the first residue of an L-Ala-L-Ser-L-Ala side chain Weissella viridescens ?
-
?

Synonyms

Synonyms Comment Organism
alanyltransferase
-
Weissella viridescens
FemXWv
-
Weissella viridescens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
radioactive coupled FemX assay Weissella viridescens
37
-
inhibition assay Weissella viridescens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
radioactive coupled FemX assay Weissella viridescens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
-
Weissella viridescens aminoacyl-tRNA analogue C
0.0041
-
-
Weissella viridescens aminoacyl-tRNA analogue C'