Literature summary for 2.3.1.B43 extracted from

  • Peng, C.; Lu, Z.; Xie, Z.; Cheng, Z.; Chen, Y.; Tan, M.; Luo, H.; Zhang, Y.; He, W.; Yang, K.; Zwaans, B.M.; Tishkoff, D.; Ho, L.; Lombard, D.; He, T.C.; Dai, J.; Verdin, E.; Ye, Y.; Zhao, Y.
    The first identification of lysine malonylation substrates and its regulatory enzyme (2011), Mol. Cell. Proteomics, 10, M111.012658.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide inhibits demalonylation and desuccinylation activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-malonyl-L-lysine Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + [protein]-N6-succinyl-L-lysine Mus musculus
-
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Sirt5 shows negligible activity toward lysine deacetylation Mus musculus ?
-
?
NAD+ + AFNQG(N6-malonyl)KIFK
-
Mus musculus nicotinamide + AFNQGKIFK + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + AYVDDTPAEQM(N6-malonyl)KAER
-
Mus musculus nicotinamide + AYVDDTPAEQMKAER + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + DSYVGDEAQSDSYVGDEAQS(N6-malonyl)KR
-
Mus musculus nicotinamide + DSYVGDEAQSDSYVGDEAQSKR + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + ETGVDLT(N6-succinyl)KDNMALQR
-
Mus musculus nicotinamide + ETGVDLTKDNMALQR + 2'-O-succinyl-ADP-ribose
-
?
NAD+ + IEEELGS(N6-malonyl)KAK
-
Mus musculus nicotinamide + IEEELGSKAK + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + SQG(N6-succinyl)KVLQATVV
-
Mus musculus nicotinamide + SQGKVLQATVV + 2'-O-succinyl-ADP-ribose
-
?
NAD+ + TAIG(N6-malonyl)KAGYTDK
-
Mus musculus nicotinamide + TAIGKAGYTDK + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + VLLPEYGGT(N6-succinyl)KVVLDDK
-
Mus musculus nicotinamide + VLLPEYGGTKVVLDDK + 2'-O-succinyl-ADP-ribose
-
?
NAD+ + [protein]-N6-malonyl-L-lysine
-
Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
-
Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
?

Synonyms

Synonyms Comment Organism
SIRT5
-
Mus musculus