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Literature summary for 2.3.1.B43 extracted from

  • Feldman, J.L.; Baeza, J.; Denu, J.M.
    Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins (2013), J. Biol. Chem., 288, 31350-31356.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-succinyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Reaction

Reaction Comment Organism Reaction ID
NAD+ + [protein]-N6-succinyl-L-lysine = nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose most efficient at catalyzing desuccinylation, medium-chain deacylation (octanoyl-, decanoyl-, dodecanoyl-) is catalyzed with lower activity Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + QTAR(N6-acetyl)KSTGG acetylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-decanoyl)KSTGG decanoylated histone H3 peptide, about 35% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 35% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-myristoyl)KSTGG myristoylated histone H3 peptide, about 15% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 30% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-propionyl)KSTGG propionylated histone H3 peptide, less than 10% compared to the activity with the succinylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
-
 ?
NAD+ + QTAR(N6-succinyl)KSTGG succinylated histone H3 peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
-
 ?
NAD+ + [protein]-N6-succinyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens
sirtuin 5
-
 Homo sapiens