Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one | i.e. GW5074, potent inhibitor for desuccinylation activity of Sirt5. 0.1 mM inhibitor reduces Sirt5 desuccinylation activity (substrate: SKEYFS-(succinylLys)-QK) to about 15%. Weaker effects in Sirt5 deacetylation assays. Deacetylation activity is reduced to about 30% in presence of 0.1 mM inhibitor | Homo sapiens | |
suramin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NXA8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + FKRGVL(N6-acetyl)KEYGVKV | acetylated peptide derived from carbamoylphosphate synthetase 1 (CPS1) | Homo sapiens | nicotinamide + FKRGVLKEYGVKV + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + SKEYFS(N6-succinyl)KQK | - |
Homo sapiens | nicotinamide + SKEYFSKQK + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [peptide derived from carbamoyl phosphate synthetase 1]-N6-acetyl-L-lysine | - |
Homo sapiens | nicotinamide + [peptide derived from carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT5 | - |
Homo sapiens |
sirtuin 5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0142 | - |
pH 7.5, temperature not specified in the publication, substrate: acetylated peptide derived from carbamoylphosphate synthetase 1 (CPS1) | Homo sapiens | suramin | |
0.0195 | - |
pH 7.5, temperature not specified in the publication, substrate: SKEYFS-(succinylLys)-QK | Homo sapiens | 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one | |
0.097 | - |
pH 7.5, temperature not specified in the publication, substrate: FKRGVL-(acetylLys)-EYGVKV | Homo sapiens | 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one |