Literature summary for 2.3.1.B43 extracted from

Lin, Z.F.; Xu, H.B.; Wang, J.Y.; Lin, Q.; Ruan, Z.; Liu, F.B.; Jin, W.; Huang, H.H.; Chen, X.
SIRT5 desuccinylates and activates SOD1 to eliminate ROS (2013), Biochem. Biophys. Res. Commun., 441, 191-195.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123	Homo sapiens	SIRT5 binds to, desuccinylates and activates the key antioxidant enzyme Cu/Zn superoxide dismutase (SOD1). SOD1-mediated reduction of reactive oxygen species (ROS) is increased when SIRT5 is co-expressed. Posttranslational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation is important for the growth of lung tumor cells	nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NXA8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123	-	Homo sapiens	nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose	-	?
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123	SIRT5 binds to, desuccinylates and activates the key antioxidant enzyme Cu/Zn superoxide dismutase (SOD1). SOD1-mediated reduction of reactive oxygen species (ROS) is increased when SIRT5 is co-expressed. Posttranslational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation is important for the growth of lung tumor cells	Homo sapiens	nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT5	-	Homo sapiens

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Release 2023.1 (January 2023)