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Literature summary for 2.3.1.B41 extracted from
- The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy (2017), Sci. Rep., 7, 11744 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + [protein]-N6-palmitoyl-L-lysine | Homo sapiens | - |
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |  |
| NAD+ + [protein]-N6-palmitoyl-L-lysine | Mus musculus | - |
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8N6T7 | - |
- |
| Mus musculus | P59941 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C2C12 cell | - |
Mus musculus | - |
| cardiac muscle fiber | - |
Homo sapiens | - |
| cardiac muscle fiber | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| muscle fibre | - |
Homo sapiens | - |
| muscle fibre | - |
Mus musculus | - |
| skeletal muscle | - |
Homo sapiens | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + [protein]-N6-palmitoyl-L-lysine | - |
Homo sapiens | nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? | |
| NAD+ + [protein]-N6-palmitoyl-L-lysine | - |
Mus musculus | nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone deacetylase | - |
Homo sapiens |
| histone deacetylase | - |
Mus musculus |
| NAD+-dependent lysine deacylase | - |
Homo sapiens |
| NAD+-dependent lysine deacylase | - |
Mus musculus |
| SIRT6 | - |
Homo sapiens |
| SIRT6 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | there are seven evolutionarily conserved mammalian sirtuins (SIRT1-7) distributed to different compartments of the cell. They possess different deacylation activities to post-translationally modulate functions of their targets influencing major cellular pathways. SIRT6 is associated with chromatin and possesses histone deacetylase as well as mono-ADP-ribosylase activities, for both of which it needs NAD+ as a co-substrate | Homo sapiens |
| evolution | there are seven evolutionarily conserved mammalian sirtuins (SIRT1-7) distributed to different compartments of the cell. They possess different deacylation activities to post-translationally modulate functions of their targets influencing major cellular pathways. SIRT6 is associated with chromatin and possesses histone deacetylase as well as mono-ADP-ribosylase activities, for both of which it needs NAD+ as a co-substrate | Mus musculus |
| malfunction | SIRT6 depletion in cardiac as well as skeletal muscle cells promotes myostatin (Mstn) expression. Upregulation of other factors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted cells is observed. Effect of SIRT6 deficiency on cardiac expression of muscle-atrophy related genes. Phenotype, detailed overview | Homo sapiens |
| malfunction | SIRT6 depletion in cardiac as well as skeletal muscle cells promotes myostatin (Mstn) expression. Upregulation of other factors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted cells is observed. SIRT6-KO mice show degenerated skeletal muscle phenotype with significant fibrosis, an effect consistent with increased levels of Mstn. SIRT6 overexpression downregulates the cytokine (TNFalpha-IFNgamma)-induced Mstn expression in C2C12 cells, and promotes myogenesis. SIRT6 overexpression mitigates atrophic effect of tumor-induced cytokines in C2C12 cells. Effect of SIRT6 deficiency on cardiac expression of muscle-atrophy related genes. Phenotype, detailed overview | Mus musculus |
| metabolism | myostatin (Mstn) and SIRT6 expression exhibit reciprocal relationship, overview | Homo sapiens |
| metabolism | myostatin (Mstn) and SIRT6 expression exhibit reciprocal relationship, overview | Mus musculus |
| physiological function | the NAD+-dependent lysine deacylases, called sirtuins, are implicated in regulation of wide variety of biological functions ranging from cellular growth, stress-resistance, metabolism, genome stability to aging. Histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. SIRT6 controls myostatin (Mstn) expression by attenuating NF-kappaB binding to the Mstn promoter. Role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factors like Mstn and activin | Homo sapiens |
| physiological function | the NAD+-dependent lysine deacylases, called sirtuins, are implicated in regulation of wide variety of biological functions ranging from cellular growth, stress-resistance, metabolism, genome stability to aging. Histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. SIRT6 controls myostatin (Mstn) expression by attenuating NF-kappaB binding to the Mstn promoter. Role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factors like Mstn and activin | Mus musculus |
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