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Literature summary for 2.3.1.B41 extracted from

  • Harlan, B.; Pehar, M.; Killoy, K.; Vargas, M.
    Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1 (2019), FASEB J., 33, 7084-7091 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Application

Application Comment Organism
medicine SIRT6 as a potential therapeutic target to prevent astrocyte-mediated motor neuron death in amyotrophic lateral sclerosis (ALS) Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene SIRT6, recombinant overexpression in astrocytes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information SIRT6 overexpression abrogates the toxicity of primary astrocytes expressing ALS-linked mutant SOD1 G93A. SIRT6 plays a central role in the protection conferred by enhancing NAD+ availability in hSOD1G93A astrocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
spinal cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
NAD+-dependent deacylase
-
 Homo sapiens
SIRT6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of SIRT6 in astrocytes by itself abrogates the neurotoxic phenotype of amyotrophic lateral sclerosis (ALS) astrocytes. Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex Homo sapiens
physiological function Sirtuins (SIRTs) are NAD+-dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance. Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing amyotrophic lateral sclerosis (ALS)-linked mutant SOD1. SIRT6 induces ARE-driven gene expression in astrocytes. And SIRT6 induces HO-1 and SRXN1 expression in astrocytes. Involvement of an additional protective pathway linking NMN treatment and increased SIRT6 activity to Nrf2 activation and upregulation of antioxidant defenses in astrocytes, overview Homo sapiens