Literature summary for 2.3.1.B41 extracted from

Hong, J.; Mei, C.; Abbas Raza, S.; Khan, R.; Cheng, G.; Zan, L.
SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKalpha signaling pathway (2020), Arch. Biochem. Biophys., 681, 108260 .

Search for more literature for 2.3.1.B41

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of the interfering adenovirus vector, specific short hairpin RNA (shRNA) for the bovine SIRT6 gene are designed, usage of shRNA-399 for SIRT6 gene silencing	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
Cl316,243	a lipolysis drug, interfers with SIRT6	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	Bos taurus	-	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	A5D7K6	Qinchuan calf cattle	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	-	Bos taurus	-
preadipocyte	SIRT6 expression pattern analysis during bovine preadipocyte differentiation, overview	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	-	Bos taurus	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Bos taurus

Expression

Organism	Comment	Expression
Bos taurus	inhibition of SIRT5 significantly promotes SIRT6 expression	up

General Information

General Information	Comment	Organism
malfunction	analysis of effects of inhibition of SIRT6 on differentiation and lipid synthesis, and related molecular mechanisms, overview. Overexpression of SIRT6 significantly inhibits the mRNA expression of key adipogenesis genes such as CCAAT enhancer binding protein alpha (CEBPalpha), FABP4, FASN, peroxisome proliferator-activated receptor gamma (PPARgamma), and stearoyl-CoA desaturase (SCD), and promotes the expression of lipolysis genes including lipoprotein lipase (LPL), while interference of SIRT6 obtains the opposite results. The lipolysis drug Cl316,243 interfering with SIRT6 significantly promotes the expression of CEBPalpha, FABP4, FASN, PPARgamma, and SCD, and inhibited the expression of LPL, while overexpression of SIRT6 results in the opposite results	Bos taurus
metabolism	SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKalpha signaling pathway, feedback synergistic regulation of SIRT5 and SIRT6 on differentiation and lipid deposition. In the differentiation process of bovine preadipocytes, inhibition of SIRT5 significantly promotes SIRT6 expression	Bos taurus
physiological function	SIRT6 is an ADP-ribosyltransferase and NAD+-dependent deacetylase of acetyl and long-chain fatty acyl groups, playing central roles in lipid and glucose metabolism. It is closely related to the occurrence of diabetes and obesity caused by overnutrition and aging. SIRT6 inhibits bovine preadipocyte differentiation and lipid synthesis, cooperating with SIRT5 to decrease lipid deposition, and repressed cell cycle arrest of preadipocytes. SIRT6 inhibits preadipocyte differentiation and lipid deposition by activating the adenosine monophosphate activated protein kinase alpha (AMPK?) pathway. SIRT6 may promote the proliferation of preadipocytes by inhibiting cell cycle arrest	Bos taurus

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Release 2023.1 (January 2023)