Protein Variants | Comment | Organism |
---|---|---|
H133Y | inactive | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [histone H3]-N6-acetyl-L-lysine18 | Homo sapiens | - |
nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [histone H3]-N6-acetyl-L-lysine18 | - |
Homo sapiens | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inactivation in cells leads to histone H3-Lys18 hyperacetylation and aberrant accumulation of pericentric transcripts | Homo sapiens |
physiological function | the enzyme deacetylates histone H3-Lys18 at pericentric chromatin to prevent mitotic errors and cellular senescence | Homo sapiens |