BRENDA - Reference to 2.3.1.B41; Id = 739132

NAD+ + [histone H3]-N6-acetyl-L-lysine56

Mus musculus

-

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

NAD+ + [histone H3]-N6-acetyl-L-lysine9

Mus musculus

-

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

Mus musculus

P59941

-

embryonic stem cell

-

Mus musculus

-

NAD+ + [histone H3]-N6-acetyl-L-lysine56

-

739132

Mus musculus

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

NAD+ + [histone H3]-N6-acetyl-L-lysine9

-

739132

Mus musculus

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

SIRT6

-

Mus musculus

sirtuin 6

-

Mus musculus

NAD+

dependent on

Mus musculus

NAD+

dependent on

Mus musculus

NAD+ + [histone H3]-N6-acetyl-L-lysine56

Mus musculus

-

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

NAD+ + [histone H3]-N6-acetyl-L-lysine9

Mus musculus

-

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

embryonic stem cell

-

Mus musculus

-

NAD+ + [histone H3]-N6-acetyl-L-lysine56

-

739132

Mus musculus

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

NAD+ + [histone H3]-N6-acetyl-L-lysine9

-

739132

Mus musculus

nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose

-

?

malfunction

enzyme knockout is associated with derepression of Oct4, Sox2 and Nanog, which in turn causes an upregulation of Tet enzymes and elevated production of 5-hydroxymethylcytosine

Mus musculus

physiological function

the enzyme controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Mus musculus

malfunction

enzyme knockout is associated with derepression of Oct4, Sox2 and Nanog, which in turn causes an upregulation of Tet enzymes and elevated production of 5-hydroxymethylcytosine

Mus musculus

physiological function

the enzyme controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Mus musculus

737930

Cea

Evidence for a role of the his ...

Homo sapiens

Blood

127

1138-1150

2016

-

1

-

2

-

1

-

1

3

-

1

-

1

-

1

-

1

-

1

-

2

-

738060

Rahnasto-Rilla

N-acylethanolamines bind to SI ...

Homo sapiens

ChemBioChem

17

77-81

2016

12

-

1

-

3

1

-

2

-

1

-

1

-

3

-

2

-

1

-

2

12

-

1

-

2

3

-

1

-

2

-

1

-

3

-

739139

Zhang

Identifying the functional con ...

Homo sapiens

Nat. Chem. Biol.

12

614-620

2016

-

1

-

4

-

2

-

1

-

4

-

2

-

1

-

1

-

4

-

1

-

4

-

1

-

739158

Tasselli

SIRT6 deacetylates H3K18Ac at ...

Homo sapiens

Nat. Struct. Mol. Biol.

23

434-440

2016

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

739225

Liu

Cyclic peptide-based potent hu ...

Homo sapiens

Org. Biomol. Chem.

14

5928-5935

2016

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

730473

Cardinale

Biochemical characterization o ...

Mus musculus

Neurochem. Res.

40

59-69

2015

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

737946

Hwang

SIRT6 protein deacetylase inte ...

Mus musculus

BMC Mol. Biol.

16

12

2015

-

1

-

1

-

1

-

3

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

737977

Feng

Sirtuin 6 promotes transformin ...

Homo sapiens

Cancer Sci.

106

559-566

2015

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

3

-

1

-

1

-

738169

Zhang

The histone deacetylase SIRT6 ...

Homo sapiens

Eur. Rev. Med. Pharmacol. Sci.

19

818-824

2015

-

1

-

2

-

3

-

1

-

1

-

1

-

1

-

3

-

1

-

738170

Maksin-Matveev

Sirtuin 6 protects the heart f ...

Mus musculus

Exp. Cell Res.

330

81-90

2015

-

3

-

2

-

2

-

1

-

1

-

2

-

1

-

738283

Hu

Posttranslational modification ...

Homo sapiens

Free Radic. Biol. Med.

79

176-185

2015

-

1

-

4

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

739132

Etchegaray

The histone deacetylase SIRT6 ...

Mus musculus

Nat. Cell Biol.

17

545-557

2015

-

2

-

2

-

1

-

2

-

2

-

1

-

1

-

2

-

1

-

2

-

2

-

739733

Tian

Sirtuin-6 inhibits cardiac fib ...

Rattus norvegicus

Transl. Res.

165

374-386

2015

-

2

-

1

-

2

-

1

-

1

-

1

-

1

2

1

-

729145

Chen

The histone deacetylase SIRT6 ...

Homo sapiens

Biochem. Biophys. Res. Commun.

446

364-369

2014

-

2

-

2

-

1

-

2

-

1

-

729362

Liu

Oxidative stress induces endot ...

Homo sapiens

Biomed Res. Int.

2014

0000

2014

-

2

-

1

-

2

-

1

-

1

-

729520

Ming

SIRT6 promotes COX-2 expressio ...

Homo sapiens, Mus musculus

Cancer Res.

74

5925-5933

2014

-

1

-

4

-

4

-

2

-

1

-

4

-

1

3

1

-

729679

Kokkonen

Studying SIRT6 regulation usin ...

Homo sapiens

Eur. J. Pharm. Sci.

0

0000

2014

-

12

-

1

-

5

-

1

-

12

-

5

-

1

-

729849

Wu

Expression and function of SIR ...

Homo sapiens

Int. J. Clin. Exp. Pathol.

7

6504-6513

2014

-

1

-

3

-

1

-

3

-

1

2

1

-

730790

Silberman

SIRT6 is required for normal r ...

Homo sapiens

PLoS One

9

e98831

2014

-

1

-

1

-

2

-

1

-

2

-

730900

Ringel

Alternate deacylating specific ...

Archaeoglobus fulgidus

Protein Sci.

23

1686-1697

2014

-

1

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

5

-

1

-

1

-

730024

Feldman

Activation of the protein deac ...

Homo sapiens

J. Biol. Chem.

288

31350-31356

2013

-

1

-

1

-

6

-

2

-

6

-

730101

Jedrusik-Bode

The sirtuin SIRT6 regulates st ...

Mus musculus

J. Cell Sci.

126

5166-5177

2013

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

730464

Jiang

SIRT6 regulates TNF-alpha secr ...

Homo sapiens

Nature

496

110-113

2013

-

1

-

7

-

1

-

2

-

1

-

10

-

2

1

-

7

1

-

1

-

1

-

7

-

1

-

1

-

10

-

1

-

7

1

-

1

-

7

730498

Gil

SIRT6 exhibits nucleosome-depe ...

Homo sapiens

Nucleic Acids Res.

41

8537-8545

2013

-

1

-

1

-

2

-

1

-

1

-

4

-

1

-

1

-

2

-

1

-

4

-

730949

Piao

Sirt6 regulates postnatal grow ...

Mus musculus

Sci. Rep.

3

0000

2013

-

2

-

1

-

728852

Zhu

Plasmodium falciparum Sir2A pr ...

Plasmodium falciparum, Plasmodium falciparum isolate 3D7

ACS Chem. Biol.

7

155-159

2012

-

1

-

3

-

3

-

1

-

8

-

1

-

4

1

-

1

-

1

-

3

-

1

-

8

-

1

-

4

1

-

1

-

4

730527

Ardestani

Sub-cellular localization, exp ...

Homo sapiens

Nucleus

3

442-451

2012

-

3

-

2

-

1

-

2

-

3

-

1

-

1

-

730706

Fischer

Sirt5 deacylation activities s ...

Archaeoglobus fulgidus

PLoS One

7

e45098

2012

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

729972

Pan

Structure and biochemical func ...

Homo sapiens

J. Biol. Chem.

286

14575-14587

2011

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

729665

Merrick

Plasmodium falciparum Sir2: an ...

Plasmodium falciparum, Plasmodium falciparum isolate 3D7

Eukaryot. Cell

6

2081-291

2007

1

-

2

-

1

-

3

-

1

-

4

1

-

1

-

2

-

1

-

1

-

4

1

-

730391

Avalos

Mechanism of sirtuin inhibitio ...

Archaeoglobus fulgidus

Mol. Cell

17

855-868

2005

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Data extracted from this reference: