Activating Compound | Comment | Organism | Structure |
---|---|---|---|
linoleic acid | EC50 value of 0.089 mM | Homo sapiens | |
luteolin | EC50 value of 0.27 mM | Homo sapiens | |
additional information | the enzyme activity is not stimulated by N-stearoylethanolamine and N-arachidonoylethanolamine | Homo sapiens | |
N-(alpha-linolenoyl)ethanolamine | - |
Homo sapiens | |
N-(gama-linolenoyl)ethanolamine | - |
Homo sapiens | |
N-linoleoylethanolamine | - |
Homo sapiens | |
N-myristoylethanolamine | - |
Homo sapiens | |
N-myristoylethanolamine | EC50 value of 0.0075 mM | Homo sapiens | |
N-oleoylethanolamine | strongest activator with EC50 value of 0.0031 mM | Homo sapiens | |
N-palmitoleoylethanolamine | - |
Homo sapiens | |
N-palmitoylethanolamine | - |
Homo sapiens | |
oleic acid | EC50 value of 0.23 mM | Homo sapiens | |
quercetin | EC50 value of 0.99 mM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
luteolin | 30% inhibition at 0.1 mM | Homo sapiens | |
additional information | not inhibited by linoleic acid, oleic acid, oleoylethanolamide, and myristoylethanolamide | Homo sapiens | |
quercetin | 38% inhibition at 0.1 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.232 | - |
[histone 3]-N6-acetyl-L-lysine9 | at pH 8.0 and 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro | ? | - |
? | |
NAD+ + [histone 3]-N6-palmitoyl-L-lysine | Homo sapiens | - |
nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Purification (Comment) | Organism |
---|---|
glutathione agarose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro | Homo sapiens | ? | - |
? | |
NAD+ + [histone 3]-N6-acetyl-L-lysine9 | - |
Homo sapiens | nicotinamide + [histone 3]-L-lysine + 2'-O-acetyl-ADP ribose | - |
? | |
NAD+ + [histone 3]-N6-palmitoyl-L-lysine | - |
Homo sapiens | nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
sirtuin 6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0041 | - |
at pH 8.0 and 37°C | Homo sapiens | luteolin | |
0.024 | - |
at pH 8.0 and 37°C | Homo sapiens | quercetin |