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Literature summary for 2.3.1.B41 extracted from

  • Feldman, J.L.; Baeza, J.; Denu, J.M.
    Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins (2013), J. Biol. Chem., 288, 31350-31356.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Reaction

Reaction Comment Organism Reaction ID
NAD+ + [protein]-N6-palmitoyl-L-lysine = nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose the enzyme prefers long chain fatty acyl groups Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG Homo sapiens ?
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
-
Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG myristoylated histone H3 peptide, about 60% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG dodecanoylated histone H3 peptide, about 60% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG hexanoylated histone H3 peptide, about 20% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG octanoylated histone H3 peptide, about 50% compared to the activity with the decanoylated peptide Homo sapiens nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
-
?

Synonyms

Synonyms Comment Organism
SIRT6
-
Homo sapiens
sirtuin 6
-
Homo sapiens