Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Micromonospora echinospora |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
8 malonyl-CoA + NADPH + H+ | Micromonospora echinospora | - |
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2 | the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin | ? | |
additional information | Micromonospora echinospora | a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Micromonospora echinospora | Q8KNG1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
8 malonyl-CoA + NADPH + H+ | - |
Micromonospora echinospora | 8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2 | the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin | ? | |
additional information | a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction | Micromonospora echinospora | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CalE8 | - |
Micromonospora echinospora |
enediyne polyketide synthase | - |
Micromonospora echinospora |
General Information | Comment | Organism |
---|---|---|
physiological function | polyketide is an authentic product of CalE8 and may be a key precursor to the enediyne core of calicheamicin | Micromonospora echinospora |