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Literature summary for 2.3.1.97 extracted from

  • Price, H.P.; Guether, M.L.; Ferguson, M.A.; Smith, D.F.
    Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects (2010), Mol. Biochem. Parasitol., 169, 55-58.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.97

Application

Application Comment Organism
drug development NMT is a putative drug target Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
additional information knockdown of NMT expression by tetracycline-inducible RNA interference leads to cell death with a block in endocytosis, but vesicle accumulation around the flagellar pocket indicates a defect in vesicular progression following endocytic fusion. Induced parasites have a wild-type or slightly enlarged Golgi apparatus, phenotype and pleiotropic effects, overview Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei presence of approximately 60 putative N-myristoylated proteins encoded by the Trypanosoma brucei genome ?
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 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information presence of approximately 60 putative N-myristoylated proteins encoded by the Trypanosoma brucei genome Trypanosoma brucei ?
-
 ?

Synonyms

Synonyms Comment Organism
myristoyl-CoA:protein N-myristoyltransferase
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 Trypanosoma brucei
NMT
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 Trypanosoma brucei