Literature summary for 2.3.1.9 extracted from

Jeon, J.M.; Kim, H.J.; Bhatia, S.K.; Sung, C.; Seo, H.M.; Kim, J.H.; Park, H.Y.; Lee, D.; Brigham, C.J.; Yang, Y.H.
Application of acetyl-CoA acetyltransferase (AtoAD) in Escherichia coli to increase 3-hydroxyvalerate fraction in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (2017), Bioprocess Biosyst. Eng., 40, 781-789 .

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Application

Application	Comment	Organism
synthesis	upon overexpression of acetyl-CoA acetyltransferase (genes AtoAD) in an engineered Escherichia coli strain, carrying polyhydroxyalkanoate synthetic genes bktB, phaB, and phaC and with propionate as a cosubstrate, the 3-hydroxyvalerate faction in Polyhydroxyalkanoate increases up to 7.3fold compared to a strain without genes AtoAD expressed in trans (67.9 mol%). Overexpression of AtoAD decreases the amount of acetyl-CoA and increases the propionyl-CoA/acetyl-CoA ratio, ultimately resulting in an increased 3-hydroxyvalerate fraction in polyhydroxyalkanoate. Synthesis of poly(3-hydroxybutanoate-co-3-hydroxyvalerate) containing 57.9 mol% of 3-hydroxyvalerate is achieved by fed-batch fermentation with propionate	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P76461	-	-

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Release 2023.1 (January 2023)