Literature summary for 2.3.1.87 extracted from

Aboalroub, A.A.; Bachman, A.B.; Zhang, Z.; Keramisanou, D.; Merkler, D.J.; Gelis, I.
Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase (2017), PLoS ONE, 12, e0177270 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Bombyx mori

Organism

Organism	UniProt	Comment	Textmining
Bombyx mori	-	-	-

Synonyms

Synonyms	Comment	Organism
AANAT3	-	Bombyx mori

General Information

General Information	Comment	Organism
physiological function	CoA and acetyl-CoA alter the conformation of the substrate binding site of arylalkylamine N-acetyltransferase to facilitate interaction with acceptor substrates. It is the presence of the acetyl group within the catalytic funnel that triggers high affinity binding. Acetyl group occupancy is relayed through a conserved salt bridge between the P-loop and the acceptor binding site, and is manifested as differential dynamics in the CoA and acetyl-CoA-bound states	Bombyx mori

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Release 2023.1 (January 2023)