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Literature summary for 2.3.1.87 extracted from

  • Noh, M.Y.; Koo, B.; Kramer, K.J.; Muthukrishnan, S.; Arakane, Y.
    Arylalkylamine N-acetyltransferase 1 gene (TcAANAT1) is required for cuticle morphology and pigmentation of the adult red flour beetle, Tribolium castaneum (2016), Insect Biochem. Mol. Biol., 79, 119-129 .
    View publication on PubMed
Search for more literature for 2.3.1.87

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Tribolium castaneum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 norepinephrine pH not specified in the publication, temperature not specified in the publication Tribolium castaneum
0.07
-
 octopamine pH not specified in the publication, temperature not specified in the publication Tribolium castaneum
0.1
-
 tryptamine pH not specified in the publication, temperature not specified in the publication Tribolium castaneum
0.11
-
 dopamine pH not specified in the publication, temperature not specified in the publication Tribolium castaneum
0.56
-
 tyramine pH not specified in the publication, temperature not specified in the publication Tribolium castaneum

Organism

Organism UniProt Comment Textmining
Tribolium castaneum A0A1J0AHX8
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + dopamine
-
 Tribolium castaneum CoA + N-acetyldopamine
-
 ?
acetyl-CoA + norepinephrine
-
 Tribolium castaneum CoA + N-acetylnorepinephrine
-
 ?
acetyl-CoA + octopamine
-
 Tribolium castaneum CoA + N-acetyloctopamine
-
 ?
acetyl-CoA + tryptamine
-
 Tribolium castaneum CoA + N-acetyltryptamine
-
 ?
acetyl-CoA + tyramine
-
 Tribolium castaneum CoA + N-acetyltyramine
-
 ?

Synonyms

Synonyms Comment Organism
AANAT1
-
 Tribolium castaneum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.5 substrate dopamine Tribolium castaneum

Expression

Organism Comment Expression
Tribolium castaneum transcripts are detected at all stages of development with lowest expressions at the embryonic and pharate pupal stages additional information

General Information

General Information Comment Organism
physiological function loss of function of AANAT1 caused by RNAi has no effect on larval and pupal development. The tanning of pupal setae, gin traps and urogomphi proceeds normally. About 70% of the resulting adults exhibit a roughened exoskeletal surface, separated elytra and improperly folded hindwings. The body wall, elytra and veins of the hindwing of the mature adults are significantly darker than those of control insects probably due to the accumulation of dopamine melanin Tribolium castaneum