Literature summary for 2.3.1.87 extracted from

Dempsey, D.R.; Jeffries, K.A.; Anderson, R.L.; Carpenter, A.M.; Rodriquez Opsina, S.; Merkler, D.J.
Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins (2014), FEBS Lett., 588, 594-599.

Search for more literature for 2.3.1.87

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0018	-	butanoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.0019	-	Arachidonoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.0036	-	oleoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.006	-	stearoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.0061	-	acetyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.0099	-	palmitoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VMG0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + serotonin	-	Drosophila melanogaster	CoA + N-acetylserotonin	-	?
acetyl-CoA + tyramine	-	Drosophila melanogaster	CoA + N-acetyltyramine	-	?
arachidonoyl-CoA + octopamine	-	Drosophila melanogaster	CoA + N-arachidonoyloctopamine	-	?
butanoyl-CoA + dopamine	-	Drosophila melanogaster	CoA + N-butanoyldopamine	-	?
oleoyl-CoA + octopamine	-	Drosophila melanogaster	CoA + N-oleoyloctopamine	-	?
palmitoyl-CoA + octopamine	-	Drosophila melanogaster	CoA + N-palmitoyloctopamine	-	?
stearoyl-CoA + octopamine	-	Drosophila melanogaster	CoA + N-stearoyloctopamine	-	?

Synonyms

Synonyms	Comment	Organism
AATNATL2	-	Drosophila melanogaster

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.043	-	Arachidonoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.059	-	stearoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.075	-	oleoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.16	-	palmitoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
0.53	-	butanoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
1.3	-	acetyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster

General Information

General Information	Comment	Organism
physiological function	isoform AANATL2 has a role in the biosynthetic formation of long-chain N-acylserotonins and N-acydopamines	Drosophila melanogaster

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
9.8	-	stearoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
16	-	palmitoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
21	-	oleoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
23	-	Arachidonoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
220	-	acetyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster
290	-	butanoyl-CoA	pH 8.0, temperature not specified in the publication	Drosophila melanogaster

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Release 2023.1 (January 2023)