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Literature summary for 2.3.1.87 extracted from

  • Migliori, M.L.; Romanowski, A.; Simonetta, S.H.; Valdez, D.; Guido, M.; Golombek, D.A.
    Daily variation in melatonin synthesis and arylalkylamine N-acetyltransferase activity in the nematode Caenorhabditis elegans (2012), J. Pineal Res., 53, 38-46.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, phylogenetic tree Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
additional information both white and blue light pulses significantly inhibit AA-NAT activity at zeitgeber time ZT18, detailed overview Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + serotonin Caenorhabditis elegans
-
CoA + N-acetylserotonin
-
?
acetyl-CoA + serotonin Caenorhabditis elegans TJ1060
-
CoA + N-acetylserotonin
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans G5EDH7 collected from NGM plates seeded with Escherichia coli NA22
-
Caenorhabditis elegans TJ1060 G5EDH7 collected from NGM plates seeded with Escherichia coli NA22
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + serotonin
-
Caenorhabditis elegans CoA + N-acetylserotonin
-
?
acetyl-CoA + serotonin
-
Caenorhabditis elegans TJ1060 CoA + N-acetylserotonin
-
?

Synonyms

Synonyms Comment Organism
AA-NAT
-
Caenorhabditis elegans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Caenorhabditis elegans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Caenorhabditis elegans

General Information

General Information Comment Organism
additional information under light-dark conditions, a rhythmic pattern of melatonin levels occurs with higher levels toward the middle of the night, peaking at zeitgeber time ZT18, and with a minimum value around ZT0-6. AA-NAT activity shows a diurnal and circadian fluctuation with higher levels of activity during the early night, both under light-dark conditions and constant darkness conditions. A peak is found around ZT12 and circadian time CT12. Light acts on AA-NAT through a well-known phototransduction mechanism that originates in the retina, is mediated by the retinohypothalamic tract, and processed in the hypothalamic suprachiasmatic nuclei, SCN, the site of the master circadian clock. From the SCN, the photic message is transduced through the sympathetic nervous system to the pineal, where noradrenergic receptors, among others, control the activity of AA-NAT Caenorhabditis elegans
physiological function melatonin influences circadian rhythms and seasonal behavioral changes in vertebrates, it is synthesized from serotonin by N-acetylation by arylalkylamine N-acetyltransferase and O-methylation by N-acetylserotonin methyltransferase, EC 2.1.1.4 Caenorhabditis elegans