Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, phylogenetic tree | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | both white and blue light pulses significantly inhibit AA-NAT activity at zeitgeber time ZT18, detailed overview | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + serotonin | Caenorhabditis elegans | - |
CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | Caenorhabditis elegans TJ1060 | - |
CoA + N-acetylserotonin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | G5EDH7 | collected from NGM plates seeded with Escherichia coli NA22 | - |
Caenorhabditis elegans TJ1060 | G5EDH7 | collected from NGM plates seeded with Escherichia coli NA22 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + serotonin | - |
Caenorhabditis elegans | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | - |
Caenorhabditis elegans TJ1060 | CoA + N-acetylserotonin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AA-NAT | - |
Caenorhabditis elegans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Caenorhabditis elegans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
additional information | under light-dark conditions, a rhythmic pattern of melatonin levels occurs with higher levels toward the middle of the night, peaking at zeitgeber time ZT18, and with a minimum value around ZT0-6. AA-NAT activity shows a diurnal and circadian fluctuation with higher levels of activity during the early night, both under light-dark conditions and constant darkness conditions. A peak is found around ZT12 and circadian time CT12. Light acts on AA-NAT through a well-known phototransduction mechanism that originates in the retina, is mediated by the retinohypothalamic tract, and processed in the hypothalamic suprachiasmatic nuclei, SCN, the site of the master circadian clock. From the SCN, the photic message is transduced through the sympathetic nervous system to the pineal, where noradrenergic receptors, among others, control the activity of AA-NAT | Caenorhabditis elegans |
physiological function | melatonin influences circadian rhythms and seasonal behavioral changes in vertebrates, it is synthesized from serotonin by N-acetylation by arylalkylamine N-acetyltransferase and O-methylation by N-acetylserotonin methyltransferase, EC 2.1.1.4 | Caenorhabditis elegans |