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Literature summary for 2.3.1.87 extracted from

  • Kang, K.; Lee, K.; Park, S.; Kim, Y.S.; Back, K.
    Enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings (2010), J. Pineal Res., 49, 176-182.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
functional ectopic overexpression of human serotonin N-acetyltransferase under the constitutive ubiquitin promoter in transgenic Oryza sativa cv. Dongjin seedlings using Agrobacterium-mediated gene transformation leading to elevated synthesis of N-acetylserotonin and melatonin in the transgenic rice plants, phenotype, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. Leaves of transgenic lines S9 and S10 contain approximately 2.5fold and 1.9fold more chlorophyll, respectively, than those of the wild type Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + serotonin Homo sapiens
-
CoA + N-acetylserotonin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + serotonin
-
Homo sapiens CoA + N-acetylserotonin
-
?
acetyl-CoA + tryptamine
-
Homo sapiens CoA + N-acetyltryptamine
-
?

Synonyms

Synonyms Comment Organism
serotonin N-acetyltransferase
-
Homo sapiens
SNA
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

General Information

General Information Comment Organism
metabolism serotonin N-acetyltransferase is a rate-limiting enzyme in melatonin biosynthesis in vertebrates Homo sapiens
physiological function serotonin N-acetyltransferase is responsible for the production of N-acetylserotonin, an intermediate of melatonin biosynthesis. Melatonin, i.e. N-acetyl-5-methoxytryptamine, has multiple functions in vertebrates, including the regulation of circadian rhythms and photoperiodism. Plant melatonin is involved in cold stress Homo sapiens