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Literature summary for 2.3.1.87 extracted from

  • Dai, F.Y.; Qiao, L.; Tong, X.L.; Cao, C.; Chen, P.; Chen, J.; Lu, C.; Xiang, Z.H.
    Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant (2010), J. Biol. Chem., 285, 19553-19560.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, quantitative expression analysis Bombyx mori

Protein Variants

Protein Variants Comment Organism
additional information construction of the mutant strain and natural polymorphism, overview. The mutant Bm-iAANAT is expressed at higher levels in sclerified tissues, such as head, thoracic legs, and anal plate, than in less sclerified tissue, i.e. epidermis Bombyx mori

Organism

Organism UniProt Comment Textmining
Bombyx mori A0EM56 arylalkylamine N-acetyltransferase wild-type; strains Dazao and C108
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Bombyx mori D6MKR1 arylalkylamine N-acetyltransferase short mutant, i.e. arylalkylamine N-acetyltransferase type 1 protein
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Bombyx mori D6MKR2 arylalkylamine N-acetyltransferase long mutant, i.e. arylalkylamine N-acetyltransferase type 2 protein
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Source Tissue

Source Tissue Comment Organism Textmining
anal plate
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Bombyx mori
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epidermis
-
Bombyx mori
-
head
-
Bombyx mori
-
integument
-
Bombyx mori
-
additional information tissue expression pattern of wild-type and mutant enzymes, overview. No expression in ovary, testis, midgut, fatbody, hemozyte, trachea, and Malpighian gland Bombyx mori
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silk gland
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Bombyx mori
-
thoracic leg
-
Bombyx mori
-

Synonyms

Synonyms Comment Organism
Bm-iAANAT
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Bombyx mori

General Information

General Information Comment Organism
malfunction the abnormal Bm-iAANAT is responsible for the mln mutant, phenotype, overview. The content of dopamine in the mln mutant is about 2times higher than in the wild-type. A greater accumulation of dopamine results from the functional deficiency of Bm-iAANAT in the mutant and that the excessive dopamine is converted into dopamine melanin, causing the darker color pattern of the sclerified regions in the mln mutant compared with the wild-type Bombyx mori
physiological function arylalkylamine-N-acetyltransferases play a role in color pattern mutation in Lepidoptera, the BmiAANAT gene plays an essential role in the pigment metabolism in silkworm Bombyx mori