KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | exposing chickens to light in the middle of the night increased the apparent Km of AANAT for tryptamine by about 10fold. The Km began to increase within 5 min of exposure to light and reached a maximum at about 30 min | Gallus gallus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | 100000 | gel filtration | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | AANAT in dark-adapted retina is bound to 14-3-3 protein. This interaction is regulated by light and phosphorylation. Phosphorylation of AANAT in darkness promotes the association with 14-3-3, which decreases the Km of the enzyme for substrate and protects the enzyme from dephosphorylation and degradation. Light exposure results in dephosphorylation of AANAT and dissociation from the complex with 14-3-3 proteins, thereby increasing the Km of the enzyme. Dissociation of the complex leads to subsequent proteasomal proteolysis of AANAT | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + tryptamine | - |
Gallus gallus | CoA + N-acetyltryptamine | - |
? |