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Literature summary for 2.3.1.85 extracted from

  • Crous-Maso, J.; Palomeras, S.; Relat, J.; Camo, C.; Martinez-Garza, U.; Planas, M.; Feliu, L.; Puig, T.
    (-)-Epigallocatechin 3-gallate synthetic analogues inhibit fatty acid synthase and show anticancer activity in triple negative breast cancer (2018), Molecules, 23, 1160 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
3-hydroxynaphthalen-1-yl 3,4,5-trihydroxybenzoate analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels and induces apoptosis Homo sapiens
4-hydroxynaphthalen-2-yl 3,4,5-trihydroxybenzoate analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels and induces apoptosis Homo sapiens
naphthalene-1,3-diyl bis(3,4,5-trihydroxybenzoate) analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels Homo sapiens
[1,1'-biphenyl]-4,4'-diyl bis(3,4,5-trihydroxybenzoate) analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P49327
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-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-