Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-chloropyrazinamide | IC50: 0.151 mM | Mycobacterium tuberculosis | |
Benzamide | 100 mM, 15% inhibition | Mycobacterium tuberculosis | |
cerulenin | no inhibitory at 3 mM, 62% inhibition at 6.0 mM | Mycobacterium tuberculosis | |
Pyrazinamide | IC50: 8.9 mM | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Mycobacterium tuberculosis | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FASI | - |
Mycobacterium tuberculosis |
fatty acid synthase I | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.055 | 0.059 | 5-chloropyrazinamide | 37°C, pH 7.4 | Mycobacterium tuberculosis | |
2.6 | - |
Pyrazinamide | 37°C, pH 7.4 | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.151 | - |
IC50: 0.151 mM | Mycobacterium tuberculosis | 5-chloropyrazinamide | |
8.9 | - |
IC50: 8.9 mM | Mycobacterium tuberculosis | Pyrazinamide |