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Literature summary for 2.3.1.85 extracted from
- Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits (1981), J. Biol. Chem., 256, 5128-5133.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-Dibromo-2-propanone | acetyl-CoA, not malonyl-CoA, protects against inactivation, both protect against cross-linking of the subunits; covalently cross-links subunits, inactivates beta-ketoacyl synthetase- and overall-fatty acid synthase reaction | Gallus gallus |  |
| iodoacetamide | inhibits beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl CoA protects | Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 220000 | - |
2 * 220000, SDS-PAGE | Gallus gallus |
| 480000 | - |
SDS-PAGE | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.2 | - |
NADPH | Gallus gallus |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 220000, SDS-PAGE | Gallus gallus |
| More | condensing enzyme activity requires both subunits | Gallus gallus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Gallus gallus |
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Release 2023.1 (January 2023)
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