Literature summary for 2.3.1.82 extracted from

Tran, T.; Chiem, K.; Jani, S.; Arivett, B.; Lin, D.; Lad, R.; Jimenez, V.; Farone, M.; Debevec, G.; Santos, R.; Giulianotti, M.; Pinilla, C.; Tolmasky, M.
Identification of a small molecule inhibitor of the aminoglycoside 6-N-acetyltransferase type Ib [AAC(6)-Ib] using mixture-based combinatorial libraries (2018), Int. J. Antimicrob. Agents, 51, 752-761 .

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-3-[(2S)-2-([[(1S)-2-amino-1-phenylethyl]amino]methyl)pyrrolidin-1-yl]-2-([(2S)-2-phenyl-2-[(3-phenylbutyl)amino]ethyl]amino)propan-1-ol	robust enzymatic inhibitor in vitro, in combination with amikacin potentiates the inhibition of growth of resistant bacteria in culture, and improves survival when used as treatment of Galleria mellonella infected with aac(6')-Ib-harboring Klebsiella pneumoniae and Acinetobacter baumannii strains	Acinetobacter baumannii
(2S)-3-[(2S)-2-([[(1S)-2-amino-1-phenylethyl]amino]methyl)pyrrolidin-1-yl]-2-([(2S)-2-phenyl-2-[(3-phenylbutyl)amino]ethyl]amino)propan-1-ol	robust enzymatic inhibitor in vitro, in combination with amikacin potentiates the inhibition of growth of resistant bacteria in culture, and improves survival when used as treatment of Galleria mellonella infected with aac(6')-Ib-harboring Klebsiella pneumoniae and Acinetobacter baumannii strains	Klebsiella pneumoniae

Organism	UniProt	Comment	Textmining
Acinetobacter baumannii	-	-	-
Acinetobacter baumannii A155	-	-	-
Klebsiella pneumoniae	-	-	-
Klebsiella pneumoniae JHCK1	-	-	-