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Literature summary for 2.3.1.82 extracted from

  • Chiem, K.; Hue, F.; Magallon, J.; Tolmasky, M.
    Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases (2018), Int. J. Antimicrob. Agents, 51, 271-273 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
clioquinol Zn2+ in complex with clioquinol reduces resistance to amikacin in Acinetobacter baumannii and Escherichia coli harboring aac(6')-Ib. In the absence of Zn2+, clioquinol does not display inhibitory activity Acinetobacter baumannii
Zn2+ Zn2+ in complex with clioquinol reduces resistance to amikacin in Acinetobacter baumannii and Escherichia coli harboring aac(6')-Ib Acinetobacter baumannii

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii A155
-
-
-

Synonyms

Synonyms Comment Organism
6'-N-acetyltransferase type Ib
-
 Acinetobacter baumannii
AAC(6')-Ib
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 Acinetobacter baumannii