Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid | identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A | Escherichia coli | |
4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid | identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | Q6SJ71 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + kanamycin A | - |
Escherichia coli | CoA + N6'-acetylkanamycin A | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.012 | - |
substrate kanamycin A, pH 7.5, temperature not specified in the publication | Escherichia coli | 2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid | |
0.015 | - |
substrate kanamycin A, pH 7.5, temperature not specified in the publication | Escherichia coli | 4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid | |
0.016 | - |
substrate acetyl-CoA, pH 7.5, temperature not specified in the publication | Escherichia coli | 4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid | |
0.035 | - |
substrate acetyl-CoA, pH 7.5, temperature not specified in the publication | Escherichia coli | 2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid |