Literature summary for 2.3.1.82 extracted from

Pourreza, A.; Witherspoon, M.; Fox, J.; Newmark, J.; Bui, D.; Tolmasky, M.E.
Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1 (2005), Antimicrob. Agents Chemother., 49, 2979-2982.

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Protein Variants

Protein Variants	Comment	Organism
D117A	complete loss of the resistance phenotype against kanamycin and amikacin	Escherichia coli
D120A	complete loss of the resistance phenotype against kanamycin and amikacin	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	encoded by plasmid pJHCMW1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + amikacin	-	Escherichia coli	?	-	?
acetyl-CoA + kanamycin	-	Escherichia coli	CoA + N6'-acetylkanamycin	-	?

Synonyms

Synonyms	Comment	Organism
aminoglycoside 6'-N-acetyltransferase type Ib	-	Escherichia coli

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Release 2023.1 (January 2023)