Cloned (Comment) | Organism |
---|---|
- |
Salmonella enterica |
Protein Variants | Comment | Organism |
---|---|---|
C109A | mutation neither abolishes activity nor alters the biphasic inactivation by iodoacetamide | Salmonella enterica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dithio-CoA | - |
Salmonella enterica | |
iodoacetamide | inactivation in a biphasic manner, half of the activity is lost rapidly and the other half more slowly, tobramycin but not acetyl-CoA protects | Salmonella enterica | |
lividomycin | - |
Salmonella enterica |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
netilmicin | mutant enzyme C109A | Salmonella enterica | |
0.008 | - |
netilmicin | wild-type enzyme | Salmonella enterica | |
0.01 | - |
acetyl-CoA | reaction with tobramycin | Salmonella enterica | |
0.012 | - |
sisomicin | wild-type enzyme | Salmonella enterica | |
0.014 | - |
neomycin C | wild-type enzyme | Salmonella enterica | |
0.017 | - |
kanamycin B | mutant enzyme C109A | Salmonella enterica | |
0.017 | - |
acetyl-CoA | reaction with tobramycin, mutant enzyme C109A | Salmonella enterica | |
0.026 | - |
tobramycin | mutant enzyme C109A | Salmonella enterica | |
0.03 | - |
dibekacin | wild-type enzyme | Salmonella enterica | |
0.05 | - |
amikacin | wild-type enzyme | Salmonella enterica | |
0.05 | - |
ribostamycin | wild-type enzyme | Salmonella enterica | |
0.066 | - |
tobramycin | wild-type enzyme | Salmonella enterica | |
0.07 | - |
acetyl-CoA | reaction with tobramycin, mutant enzyme C109A/C70A | Salmonella enterica | |
0.075 | - |
amikacin | mutant enzyme C109A | Salmonella enterica | |
0.079 | - |
kanamycin B | wild-type enzyme | Salmonella enterica | |
0.105 | - |
kanamycin A | wild-type enzyme | Salmonella enterica | |
0.25 | - |
neomycin C | mutant enzyme C109A/C70A | Salmonella enterica | |
0.27 | - |
propionyl-CoA | reaction with tobramycin, wild-type enzyme | Salmonella enterica | |
0.46 | - |
netilmicin | mutant enzyme C109A/C70A | Salmonella enterica | |
0.53 | - |
neomycin A | - |
Salmonella enterica | |
0.54 | - |
tobramycin | mutant enzyme C109A/C70A | Salmonella enterica | |
0.82 | - |
malonyl-CoA | reaction with tobramycin, wild-type enzyme | Salmonella enterica | |
0.9 | - |
kanamycin B | mutant enzyme C109A/C70A | Salmonella enterica | |
9.3 | - |
butyryl-CoA | reaction with tobramycin, wild-type enzyme | Salmonella enterica |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
17000 | - |
2 * 17000, SDS-PAGE | Salmonella enterica |
17173 | - |
2 * 17173, calculation from nucleotide sequence | Salmonella enterica |
17184 | - |
2 * 17184, electrospray ionization mass spectrometry | Salmonella enterica |
35000 | - |
gel filtration | Salmonella enterica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Salmonella enterica | involved in resistance to antibiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | - |
Salmonella enterica | CoA + N6'-acetylamikacin | - |
? | |
acetyl-CoA + dibekacin | - |
Salmonella enterica | CoA + N6'-acetyldibekacin | - |
? | |
acetyl-CoA + kanamycin A | - |
Salmonella enterica | CoA + N6'-acetylkanamycin A | - |
? | |
acetyl-CoA + kanamycin B | - |
Salmonella enterica | CoA + N6'-acetylkanamycin B | - |
? | |
acetyl-CoA + neomycin A | - |
Salmonella enterica | CoA + N6'-acetylneomycin A | - |
? | |
acetyl-CoA + neomycin C | - |
Salmonella enterica | CoA + N6'-acetylneomycin C | - |
? | |
acetyl-CoA + netilmicin | - |
Salmonella enterica | CoA + N6'-acetylnetilmicin | - |
? | |
acetyl-CoA + ribostamycin | - |
Salmonella enterica | CoA + N6'-acetylribostamycin | - |
? | |
acetyl-CoA + sisomicin | - |
Salmonella enterica | CoA + N6'-acetylsisomicin | - |
? | |
acetyl-CoA + tobramycin | - |
Salmonella enterica | CoA + N6'-acetyltobramycin | - |
? | |
butyryl-CoA + tobramycin | - |
Salmonella enterica | CoA + N6'-butyryltobramycin | - |
? | |
malonyl-CoA + tobramycin | - |
Salmonella enterica | CoA + N6'-malonyltobramycin | - |
? | |
additional information | involved in resistance to antibiotics | Salmonella enterica | ? | - |
? | |
propionyl-CoA + tobramycin | tobramycin exhibits a rapid, tobramycin-independent rate of hydrolysis that is linearly proportional to enzyme | Salmonella enterica | CoA + N6'-propionyltobramycin | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 17000, SDS-PAGE | Salmonella enterica |
dimer | 2 * 17173, calculation from nucleotide sequence | Salmonella enterica |
dimer | 2 * 17184, electrospray ionization mass spectrometry | Salmonella enterica |