Application | Comment | Organism |
---|---|---|
analysis | direct method to assay HGSNAT enzymatic activity using fluorescent BODIPY-glucosamine as a substrate. The assay is specific and potentially applicable for the biochemical diagnosis of mucopolysaccharidosis III type and high-throughput screening for HGSNAT inhibitors | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in COS-7 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucosamine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q68CP4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + BODIPY-beta-D-glucosaminide | - |
Homo sapiens | CoA + BODIPY-N-acetyl-beta-D-glucosaminide | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.26 | - |
D-glucosamine | pH 6.5, 37°C | Homo sapiens |