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Literature summary for 2.3.1.78 extracted from

  • Ausseil, J.; Landry, K.; Seyrantepe, V.; Trudel, S.; Mazur, A.; Lapointe, F.; Pshezhetsky, A.V.
    An acetylated 120-kDa lysosomal transmembrane protein is absent from mucopolysaccharidosis IIIC fibroblasts: a candidate molecule for MPS IIIC (2006), Mol. Genet. Metab., 87, 22-31.
    View publication on PubMed
Search for more literature for 2.3.1.78

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosomal membrane lysosomal transmembrane protein Homo sapiens 5765
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
 x * 120000, SDS-PAGE Homo sapiens
240000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q68CP4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skin fibroblast the enzyme is present in the lysosomal membranes purified from the normal human skin fibroblasts, but absent in those from the skin fibroblasts of patients with mucopolysaccharidosis IIIC Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.34
-
-
 Homo sapiens
5.351
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-methylumbelliferyl-alpha-D-glucosaminide
-
 Homo sapiens CoA + 4-methylumbelliferyl-N-acetyl-alpha-D-glucosaminide
-
 ?

Subunits

Subunits Comment Organism
? x * 120000, SDS-PAGE Homo sapiens
More two major bands are detected by SDS-PAGE, 12000 Da (catalytic subunit) and 145000 Da Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens chromatofocusing
-
 7.4