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Literature summary for 2.3.1.75 extracted from

  • Arne, J.M.; Widjaja-Adhi, M.A.; Hughes, T.; Huynh, K.W.; Silvaroli, J.A.; Chelstowska, S.; Moiseenkova-Bell, V.Y.; Golczak, M.
    Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (2017), J. Lipid Res., 58, 719-730 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
11-cis-retinyl acetate the presence of 11-cis-retinyl acetate leads to reduction in esterification of 9-cis-retinol Mus musculus
11-cis-retinyl laurate the presence of 11-cis-retinyl laurate leads to reduction in esterification of 9-cis-retinol Mus musculus
11-cis-retinyl palmitate the presence of 0.01 mM 11-cis-retinyl palmitate significantly reduces the amount of 9-cis-retinyl ester produced by the enzyme. 11-cis-retinyl palmitate also inhibits13-cis- and all-trans-retinol esterification, but has no effect on formation of 11-cis-retinyl myristate Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02359
-
all-trans-retinol at pH 7.0 and 37°C Mus musculus
0.02376
-
9-cis-retinol at pH 7.0 and 37°C Mus musculus
0.02622
-
11-cis-retinol at pH 7.0 and 37°C Mus musculus
0.03518
-
13-cis-retinol at pH 7.0 and 37°C Mus musculus
0.04898
-
Tetradecanol at pH 7.0 and 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + a long-chain alcohol Mus musculus
-
CoA + a long-chain ester
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6E1M8
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography and Superdex S200 gel filtration Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + a long-chain alcohol
-
Mus musculus CoA + a long-chain ester
-
?
myristoyl-CoA + 11-cis-retinol preferred substrate Mus musculus 11-cis-retinyl myristate + CoA
-
?
myristoyl-CoA + 13-cis-retinol
-
Mus musculus 13-cis-retinyl myristate + CoA
-
?
myristoyl-CoA + 9-cis-retinol
-
Mus musculus 9-cis-retinyl myristate + CoA
-
?
myristoyl-CoA + all-trans-retinol
-
Mus musculus all-trans-retinyl myristate + CoA
-
?
myristoyl-CoA + tetradecanol
-
Mus musculus tetradecanyl myristate + CoA
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
acyl-CoA wax alcohol acyltransferase 2
-
Mus musculus
AWAT2
-
Mus musculus
MFAT
-
Mus musculus
multifunctional O-acyltransferase
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0042 0.0045 11-cis-retinyl palmitate at pH 7.0 and 37°C Mus musculus