Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-cis-retinyl acetate | the presence of 11-cis-retinyl acetate leads to reduction in esterification of 9-cis-retinol | Mus musculus | |
11-cis-retinyl laurate | the presence of 11-cis-retinyl laurate leads to reduction in esterification of 9-cis-retinol | Mus musculus | |
11-cis-retinyl palmitate | the presence of 0.01 mM 11-cis-retinyl palmitate significantly reduces the amount of 9-cis-retinyl ester produced by the enzyme. 11-cis-retinyl palmitate also inhibits13-cis- and all-trans-retinol esterification, but has no effect on formation of 11-cis-retinyl myristate | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02359 | - |
all-trans-retinol | at pH 7.0 and 37°C | Mus musculus | |
0.02376 | - |
9-cis-retinol | at pH 7.0 and 37°C | Mus musculus | |
0.02622 | - |
11-cis-retinol | at pH 7.0 and 37°C | Mus musculus | |
0.03518 | - |
13-cis-retinol | at pH 7.0 and 37°C | Mus musculus | |
0.04898 | - |
Tetradecanol | at pH 7.0 and 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + a long-chain alcohol | Mus musculus | - |
CoA + a long-chain ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6E1M8 | - |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose column chromatography and Superdex S200 gel filtration | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + a long-chain alcohol | - |
Mus musculus | CoA + a long-chain ester | - |
? | |
myristoyl-CoA + 11-cis-retinol | preferred substrate | Mus musculus | 11-cis-retinyl myristate + CoA | - |
? | |
myristoyl-CoA + 13-cis-retinol | - |
Mus musculus | 13-cis-retinyl myristate + CoA | - |
? | |
myristoyl-CoA + 9-cis-retinol | - |
Mus musculus | 9-cis-retinyl myristate + CoA | - |
? | |
myristoyl-CoA + all-trans-retinol | - |
Mus musculus | all-trans-retinyl myristate + CoA | - |
? | |
myristoyl-CoA + tetradecanol | - |
Mus musculus | tetradecanyl myristate + CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
acyl-CoA wax alcohol acyltransferase 2 | - |
Mus musculus |
AWAT2 | - |
Mus musculus |
MFAT | - |
Mus musculus |
multifunctional O-acyltransferase | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0042 | 0.0045 | 11-cis-retinyl palmitate | at pH 7.0 and 37°C | Mus musculus |