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Literature summary for 2.3.1.75 extracted from
- A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters (2005), J. Lipid Res., 46, 2388-2397.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| chromosomal location, expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells and in COS-7 cells | Homo sapiens |
| MFAT, DNA and amino acid sequence determination and analysis, localized on the X chromosome, expression of the N-terminally FLAG-tagged enzyme in Spodoptera frugierda Sf9 cells using the baculovirus transfection system, or in COS-7 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme plays an important role in lipid metabolism in human skin, overview | ? | - |
? | |
| additional information | Homo sapiens | the multifunctional enzyme plays an important role in lipid metabolism in human skin | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | Q6E213 | MFAT | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| liver | very low expression level | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung | very low expression level | Homo sapiens | - |
| pancreas | very low expression level | Homo sapiens | - |
| skin | predominantly | Homo sapiens | - |
| skin | high expression level | Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| testis | very low expression level | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-hexadecandiol + palmitoyl-CoA | - |
Homo sapiens | ? | - |
? | |
| 1-hexadecanol + palmitoyl-CoA | - |
Homo sapiens | CoA + hexadecylpalmitate | - |
? | |
| additional information | the enzyme plays an important role in lipid metabolism in human skin, overview | Homo sapiens | ? | - |
? | |
| additional information | the multifunctional enzyme plays an important role in lipid metabolism in human skin | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity, overview, a human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters, overview, the enzyme catalyzes also the reactions of EC 2.3.1.20 and EC 2.3.1.22 | Homo sapiens | ? | - |
? | |
| additional information | the multifunctional O-acetyltransferase is catalyzing the reactions of the wax synthase, of the diacylglycerol transferase, EC 2.3.1.20, of the monoacylglycerol transferase, EC 2.3.1.22, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview | Homo sapiens | ? | - |
? | |
| palmitoyl-CoA + 1,2-hexadecandiol | - |
Homo sapiens | ? | - |
? | |
| palmitoyl-CoA + all-trans-retinol | - |
Homo sapiens | ? | - |
? | |
| palmitoyl-CoA + dioleoylglycerol | - |
Homo sapiens | ? | - |
? | |
| palmitoyl-CoA + hexadecanol | - |
Homo sapiens | CoA + hexadecyl palmitate | - |
? | |
| palmitoyl-CoA + monooleoylglycerol | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acyl-CoA:fatty acyl alcohol acyltransferase | - |
Homo sapiens |
| MFAT | - |
Homo sapiens |
| More | cf. EC 2.3.1.20 and EC 2.3.1.22, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family | Homo sapiens |
| More | the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family | Homo sapiens |
| multifunctional O-acyltransferase | - |
Homo sapiens |
| wax synthase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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